Nathaniel Guy Mahieu

Computational Metabolomics

An inquisitive student advancing metabolomic technology to pursue answers to human disease.

Nathaniel Guy Mahieu

Education

Washington University in St. Louis

Chemistry - Metabolomics

2011 -

PhD Chemistry Candidate; Research in the lab of Dr. Gary J. Patti; Teaching Organic Chemistry Lab I, II and Biochemistry. Awarded the GAANN Fellowship, MSACL Young Investigator Award and Podium Presentation, ASMS Metabolomics Short Course Guest Instructor.

University of Missouri

Chemistry and Biochemistry

2007 - 2011

BS Biochemistry with honors, BS Chemistry with honors; GPA: 3.500; Awarded the Dean's List recognition all eight semesters; Awarded the Life Sciences Undergraduate Research Opportunities Program; Awarded the Undergraduate Research Mentorship Program; Awarded best senior thesis.

Experience

Graduate Reseacher

Lab of Dr. Gary J. Patti

2011 -

Research: mass spectrometry based metabolomics; increasing the density and throughput of metabolomic data; improving data processing quality; exploring complex relationships within metabolomic data.

Teaching Assistant

Washington University

2011 -

Courses: Organic Chemistry Lab I; Organic Chemistry Lab II; Biochemistry II
Training: Designing and Facilitating Inquiry-Based Laboratory Teaching; Designing and Teaching an Introductory STEM Course; Indtroduction to the Scholarship of Teaching and Learning; Active Learning Strategy, Problem-Based Learning

Undergraduate Researcher

Lab of Dr. Kent S. Gates

2010

Conceptualized and executed reactions to synthesize a 2-nitroimidazole derivative. Collected UV-Vis spectra. Sponsored by the Life Sciences Undergraduate Research Oppotunity award and the Undergraduate Research Mentorship Program award.

Tutor

Mizzou Athletic Department, Total Person Program

2009 - 2010

Tutored Mizzou's varsity athletes in chemistry and mathematics; motivated them in their academic pursuits.

Quality Control Analyst

TEVA Pharmaceuticals

2008

Preformed FDA mandated analyses on chemical precursors and products. Certified on ethics training, good manufacturing practices, and all tests performed. Kept thorough notebook of all tasks.

Skills

Chemistry

LC/MS based metabolomics, mass spectrometry (ESI QqQ and QTOF operation and maintanence), high performance liquid chromatography, Warpgroup, custom XCMS analysis, CAMERA, METLIN, R data analysis, reproducible research, protein purification, synthesis

Informatics

R, Github, reproducible research, dynamic time warping, graph analysis. R packages: knitr, dtw, igraph, plyr, reshape2, ggplot2, matrixStats

Wrote R packages: warpgroup, credential

Inquisitive Drive

Dream big.

Web Development

HTML, CSS, JS, PHP, Ruby, Rails, MySQL, Illustrator, Github.

Publications

A roadmap for the XCMS family of software solutions in metabolomics.

2015

Mahieu NG, Genenbacher JL, Patti GJCurr Opin Chem Biol., 2015
doi: 10.1016/j.cbpa.2015.11.009

Warpgroup: increased precision of metabolomic data processing by consensus integration bound analysis.

2015

Mahieu NG, Spalding JL, Patti GJ. Bioinformatics., 2015
doi: 10.1093/bioinformatics/btv5

Credentialing features: a platform to benchmark and optimize untargeted metabolomic methods.

2014

Mahieu NG, Huang X, Chen YJ, Patti GJ. Anal Chem., 2014
doi: 10.1021/ac503092d

After the feature presentation: technologies bridging untargeted metabolomics and biology.

2014

Cho K, Mahieu NG, Johnson SL, Patti GJ. Curr. Opin. Biotechnol., 2014, 28C, 143-148
doi: 10.1016/j.copbio.2014.04.006

An untargeted metabolomic workflow to improve structural characterization of metabolites.

2013

Nikolskiy I, Mahieu NG, Chen YJ, Tautenhahn R, Patti GJ. Anal. Chem., 2013, 85 (16), 7713-7719
doi: 10.1021/ac400751j

A View from Above: Cloud Plots to Visualize Global Metabolomic Data

2013

Gary J. Patti, Ralf Tautenhahn, Duane Rinehart, Kevin Cho, Leah P. Shriver, Marianne Manchester, Igor Nikolskiy, Caroline H. Johnson, Nathaniel G. Mahieu, and Gary Siuzdak. Anal. Chem., 2013, 85 (2), 798-804
doi: 10.1021/ac3029745

The Disruption of Celf6, a Gene Identified by Translational Profiling of Serotonergic Neurons, Results in Autism-Related Behaviors

2013

Joseph D. Dougherty, Susan E. Maloney, David F. Wozniak, Michael A. Rieger, Lisa Sonnenblick, Giovanni Coppola, Nathaniel G. Mahieu, Juliet Zhang, Jinlu Cai, Gary J. Patti, Brett S. Abrahams, Daniel H. Geschwind, and Nathaniel Heintz J. Neurosci., 2013, 33 (7), 2732-2753
doi: 10.1523/JNEUROSCI.4762-12.2013

Awards

American Society for Mass Spectrometry (ASMS) Travel Award and Poster Presenter

2014

Mass Spectrometry Applications to the Clinical Lab (MSACL) Young Investigator Award and Podium Presenter

2013

GAANN Fellowship

2012

Undergraduate Research Mentorship Program

2011

Life Sciences Undergraduate Research Opportunity Program

2010